Akerman LLP

Three Brickell City Centre, Suite 1100

Miami, Florida 33131

Tel: (305) 374-5600

U.S. Securities and Exchange Commission

100 F Street, NE

Washington, DC 20549

Dear Sir/Madam:

On behalf of Rennova Health, Inc. (the “Company”), we hereby submit this letter to notify the Securities and Exchange Commission (the “SEC”) of an inadvertent EDGAR filing submission error. On June 17, 2016, the Company filed Post-Effective Amendment No. 1 to its FORM S-1 (Accession No. 0001019687-16-0067258) under EDGAR Form Type POSAM with the SEC via EDGAR. The EDGAR Submission Data page had an incorrect 33 Act File Number (333-211515), while it should have been 333-208157. The Registrant hereby respectfully withdraws such POSAM filing and will refile a POSAM form with the correct Submission data as soon as practicable.

If you have any questions or comments concerning the above, please contact the undersigned at (305) 374-5600.