Annual report pursuant to Section 13 and 15(d)

Consolidated Statement of Stockholders' Deficit

Consolidated Statement of Stockholders' Deficit - USD ($)	Preferred Stock [Member]	Common Stock [Member]	Additional Paid in Capital [Member]	Accumulated Deficit [Member]	Total
Balance at Dec. 31, 2016	$ 102		$ 45,754,866	$ (60,640,864)	$ (14,885,896)
Balance, shares at Dec. 31, 2016	10,234	373
Conversion of preferred stock into common stock	$ (78)		78
Conversion of preferred stock into common stock, shares	(7,785)	742
Preferred stock issued for business acquisition	$ 17,500		156,597		174,097
Preferred stock issued for business acquisition, shares	1,750,000
Common stock issued in exchange for warrants			697,485		697,485
Common stock issued in exchange for warrants, shares		1,330
Shares issued in settlement of notes payable and warrants			440,000		440,000
Shares issued in settlement of notes payable and warrants, shares		53
Exchange of preferred stock for convertible debentures	$ (22)		(2,173,978)		(2,174,000)
Exchange of preferred stock for convertible debentures, shares	(2,174)
Conversion of debentures into common stock		$ 4	7,306,310		7,306,314
Conversion of debentures into common stock, shares		36,571
Rounding up of common shares in connection with reverse stock split
Rounding up of common shares in connection with reverse stock split, shares		1
Reduction in common stock in connection with reverse stock split			(6,675)		(6,675)
Reduction in common stock in connection with reverse stock split, shares		(5)
Common stock granted to employees
Discount on convertible debentures			252,143		252,143
Warrants and beneficial conversion features related to the issuance of convertible notes			24,177,258		24,177,258
Stock-based compensation			58,278		58,278
Deemed dividend from trigger of down round provision feature			53,341,619	(53,341,619)
Restricted stock issued to employees			244,768		244,768
Restricted stock issued to employees, shares		364
Common stock issued for services and severance			161,003		161,003
Common stock issued for services and severance, shares		83
Shares returned to treasury
Shares returned to treasury, shares		(10)
Beneficial conversion feature of Series 1-1 preferred stock			(1,860,294)		(1,860,294)
Conversion of Series I-2 Preferred stock into common stock
Net loss				(55,197,942)	(55,197,942)
Balance at Dec. 31, 2017	$ 17,502	$ 4	128,549,458	(169,180,425)	(40,613,461)
Balance, shares at Dec. 31, 2017	1,750,275	39,502
Conversion of debentures into common stock		$ 422	8,127,622		8,128,044
Conversion of debentures into common stock, shares		4,221,601
Stock-based compensation			285,992		285,992
Deemed dividend from trigger of down round provision feature			231,843,826	(231,843,826)
Restricted stock issued to employees		$ 14	477,919		477,933
Restricted stock issued to employees, shares		142,667
Shares returned to treasury
Shares returned to treasury, shares		(123)
Conversion of Series I-2 Preferred stock into common stock		$ 10,634	1,502,471		1,513,105
Conversion of Series I-2 Preferred stock into common stock, shares		106,335,991
Conversion of Series H Preferred stock into common stock		$ 4	(4)
Conversion of Series H Preferred stock into common stock, shares	(50)	40,000
Common stock issued in cashless exercise of warrants		$ 1,779	4,617,371		4,619,150
Common stock issued in cashless exercise of warrants, shares		17,788,579
Shares issued in settlement of notes payable	$ 2,500		247,500		250,000
Shares issued in settlement of notes payable, shares	250,000
Exchange of convertible debentures for Series I-2 Preferred Stock			1,420		1,420
Adjust for fractional shares in reverse stock split
Adjust for fractional shares in reverse stock split, shares		(944)
Beneficial conversion feature of convertible debentures			192,308		192,308
Net loss				(14,022,355)	(14,022,355)
Balance at Dec. 31, 2018	$ 20,002	$ 12,857	$ 375,845,883	$ (415,046,606)	$ (39,167,864)
Balance, shares at Dec. 31, 2018	2,000,225	128,567,273