Annual report pursuant to Section 13 and 15(d)

10. Stockholders' Equity (Details - Option activity)

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10. Stockholders' Equity (Details - Option activity) - Stock Options [Member] - $ / shares
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Number of options      
Options outstanding 53,356 263,367  
Options granted 693,287 5,059  
Options expired (4,284) (203,373)  
Options issued for merger   1,957  
Options forfeited (33,334)    
Options exercised   (13,654)  
Options outstanding 709,025 53,356 263,367
Options exercisable 635,690    
Weighted average exercise price      
Options outstanding, beginning balance $ 231.96 $ 205.97  
Options granted 118.55 292.80  
Options expired 28.69 221.13  
Options issued for merger   1,270.60  
Options forfeited 21.60    
Options exercised   75.00  
Options outstanding, ending blance 129.43 $ 231.96 $ 205.97
Options exercisable $ 145.84    
Weighted average contractual term      
Options outstanding, ending balance 8 years 11 months 5 days 2 years 10 months 24 days 4 years 5 months 23 days